Investigating brain uptake of a non-targeting monoclonal antibody after intravenous and intracerebroventricular administration

HIGHLIGHTS

• who: August et al. from the Vilnius University, Lithuania Center (UTHSC), United States have published the Article: Investigating brain uptake of a non-targeting monoclonal antibody after intravenous and intracerebroventricular administration, in the Journal: (JOURNAL)
• what: 2.5.4 Pathway analysis Pathway analysis for elimination was performed to quantify the contribution of the local drug clearance in the brain to total body clearance of the EGFRvIII-TCB using the model presented in_(Bloomingdale et_al, 2021). The model described the PK of EGFRvIII-TCB in serum, CSF, and ISFbrain after IV administration of 15 mg/kg . . .
  

   

  

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