Investigating crispr/cas9 gene drive for production of disease-preventing prion gene alleles

HIGHLIGHTS

  • who: Andrew R. Castle and collaborators from the Centre for Prions and Protein Folding Diseases, University of Alberta, Edmonton, Alberta, Canada have published the article: Investigating CRISPR/Cas9 gene drive for production of disease-preventing prion gene alleles, in the Journal: PLOS ONE of 27/03/2022
  • what: Inspired by demonstrations of gene drive in caged mosquito species the authors aimed to test whether a CRISPR/Cas9-based gene drive mechanism could in principle promote the spread of a null Prnp allele among mammalian populations. Although improving gene editing performance in cultured cells was not . . .

     

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