HIGHLIGHTS
- who: Amit Mahindra and collaborators from the Queen`s University Belfast, Research Portal: have published the Article: Investigating the Structure-Activity Relationship of 1,2,4-Triazine G-Protein-Coupled Receptor 84 (GPR84) Antagonists, in the Journal: (JOURNAL) of August/10,/2022
- what: The authors report a substantial SAR of this compound and novel highly potent analogues with improved druglike properties. A molecular docking study was carried out to provide a structural hypothesis of an antagonist binding mode. Antagonist 4 was shown to be highly selective for GPR84 when assessed against a panel of 167 . . .
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