HIGHLIGHTS
- who: Sara Bisi from the Department University of have published the research work: IRSp53 controls plasma membrane shape and polarized transport at the nascent lumen in epithelial tubules, in the Journal: NATURE COMMUNICATIONS NATURE COMMUNICATIONS of 22/09/2010
- what: The authors focused the attention on RAB35. The authors focused on the two-cell stage of MDCK cells plated onto a Matrigel cushion. The analysis was therefore focused on this organ, and specifically on its tubular architecture. The authors show that IRSp53, a CDC42 effector that can sense Ptdins(4,5)P2-rich negative membrane . . .
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