Isl1 directly regulates fgf10 transcription during human cardiac outflow formation

HIGHLIGHTS

  • who: ISL et al. from the Center for Human Disease Modeling, Department of Cell Biology, Duke Medical Center, Durham, North Carolina, United States of America, UPMC Univ, CNRS have published the article: ISL1 Directly Regulates FGF10 Transcription during Human Cardiac Outflow Formation, in the Journal: (JOURNAL) of January/27,/2012
  • what: The authors demonstrate not only that ISL1 is co-expressed with other transcription factors in the cardiac primordium, but that in_vivo it directly binds and positively regulates the transcription of FGF10.
  • how: Despite the absence of a palindromic T-box consensus site . . .

     

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