Isoalantolactone induces cell cycle arrest, apoptosis and autophagy in colorectal cancer cells

HIGHLIGHTS

• who: Ying Wang and colleagues from the Macau of Science and Technology, Macao SAR, China have published the research: Isoalantolactone Induces Cell Cycle Arrest, Apoptosis and Autophagy in Colorectal Cancer Cells, in the Journal: (JOURNAL)
• what: The authors show that blocking autophagy using CQ or Baf-A1 further reduced the viability of IATL-treated cells, suggesting that IATL initiates cytoprotective autophagy in CRC cells. The authors showed that IATL inhibits mTORC1 activity in CRC cells, as indicated by the lowered protein levels of p-mTOR and p-70S6K after a 24-h treatment with IATL . . .
  

   

  

  If you want to have access to all the content you need to log in!

  Thanks :)

  Username or E-mail:

  If you don't have an account, you can create one here.