Isocitrate dehydrogenase 1 mutation drives leukemogenesis by pdgfra activation due to insulator disruption in acute myeloid leukemia (aml)

HIGHLIGHTS

• who: Sophie Steinhu00e4user from the (UNIVERSITY) have published the article: Isocitrate dehydrogenase 1 mutation drives leukemogenesis by PDGFRA activation due to insulator disruption in acute myeloid leukemia (AML), in the Journal: (JOURNAL) of 21/Nov/2022
• what: The aim of this study was to investigate the impact of the IDH1 p.R132H mutation by CTCF site hypermethylation, disruption of 3D DNA conformation and subsequent gene_expression changes in AML. The authors provide first evidence that PDGFRA upregulation occurs as a result of disrupted DNA loop formation and subsequent loss of gene insulation due to CpG hypermethylation . . .
  

   

  

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