HIGHLIGHTS
- who: Thekla Cordes and Christian M. Metallo from the Department of Bioengineering, University of California, Gilman Drive, La Jolla, San Diego, CA, USA have published the research: Itaconate Alters Succinate and Coenzyme A Metabolism via Inhibition of Mitochondrial Complex II and Methylmalonyl-CoA Mutase, in the Journal: Metabolites 2021, 11, 117. of /2021/
- future: More research is needed to distinguish the metabolic impact of itaconate and other potential degradation products including itaconyl-CoA citramalate and mesaconate . Itaconate degradation pathway is an exciting future research direction to discover novel metabolites with potential bioactive and regulatory functions . . .
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