HIGHLIGHTS
- who: Dominique A. Garrison and colleagues from the Division of Pharmaceutics and Pharmacology, The Ohio State University, Columbus, OH, USA have published the paper: Itraconazole-Induced Increases in Gilteritinib Exposure Are Mediated by CYP3A and OATP1B, in the Journal: Molecules 2022, 6815 of /2022/
- what: The authors demonstrate that pretreatment with itraconazole is associated with a significant increase in the systemic exposure to gilteritinib in mice recapitulating the observed clinical drug-drug interaction. The aim of this study to characterize theincluding relative xenobiotic contribution of CYP3A-mediated and otherwas elimination pathways, OATP1B-type transportersmetabolism , that . . .
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