Itraq-based proteomic study on monocyte cell model discovered an association of lamp2 downregulation with hiv-1 latency

HIGHLIGHTS

• What: This study provides new insights into the mechanism of HIV-1 and potential strategies for eradicating HIV-1 reservoirs by targeting expression. † and equally contributed to this work. In the analysis of differential protein expression involving LAMP2, CD55, ITGA6, and CD47, U1, U937, J-Lat, and Jurkat cells were employed. In this study, 66 proteins associated with immunity were identified, of which, 33 were downregulated, and 20 upregulated in U1 cells compared to U937, with cellular components in the PM.
• Who: Proteomics et al. from the , (, cells latently infected with HIV-1) [14] and . . .
  

   

  

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