Jak3, stat3, and stat5 inhibit expression of mir-22, a novel

HIGHLIGHTS

• who: Top from the Department Immunology and Microbiology, University Copenhagen, Copenhagen, Denmark have published the paper: Jak3, STAT3, and STAT5 inhibit expression of miR-22, a novel, in the Journal: (JOURNAL)
• what: The authors show that (i) malignant T cells display a decreased expression a tumor suppressor miRNA miR-22 when compared to non-malignant T cells (ii) STAT5 binds the promoter the miR-22 host gene and_(iii) inhibition Jak3 STAT3 and STAT5 triggers increased expression pri-miR-22 and miR-22. The authors provide the first evidence that de-regulated Jak3/ STAT3/STAT5 . . .
  

   

  

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