HIGHLIGHTS
- who: Sarah Cooper from the Developmental Epigenetics, Department of Biochemistry, University of Oxford, South Parks Road, Oxford , QU, Institut Curie, CNRS , have published the research work: Jarid2 binds mono-ubiquitylated H2A lysine 119 to mediate crosstalk between Polycomb complexes PRC1 and PRC2, in the Journal: NATURE COMMUNICATIONS NATURE COMMUNICATIONS of 28/Nov/2016
- what: The authors demonstrate a critical role for the cofactor in mediating the interaction of with H2AK119u1. In experiments performed using recombinant nucleosomes, the authors demonstrate that Jarid2 directly binds to H2AK119u1, and that this interaction involves a UIM in the Jarid2 . . .
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