Joint degeneration in a mouse model of pseudoachondroplasia: er stress, inflammation, and block of autophagy

HIGHLIGHTS

• who: Jacqueline T. Hecht and collaborators from the Department of Pediatrics, McGovern Medical School, The University of Texas Health Science Center at Houston, TX, USA have published the paper: Joint Degeneration in a Mouse Model of Pseudoachondroplasia: ER Stress, Inflammation, and Block of Autophagy, in the Journal: (JOURNAL)
• what: The authors focused on delineating the effect of mutant-COMP on joint health in the PSACH mouse model and the timing of joint degeneration. In this study, articular cartilage was evaluated for ER stress, inflammation, autophagy block, proteoglycans, and pro-degradative processes and the timing of . . .
  

   

  

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