HIGHLIGHTS
- who: Nathan J. Klingensmith and collaborators from the DepartmentEmory University of Medicine, Atlanta, Georgia, USA have published the article: Junctional adhesion molecule-A deletion survival in murine model of sepsis, in the Journal: (JOURNAL)
- what: The authors show that septic JAM-A -/- mice have increased gut permeability yet paradoxically have decreased bacteremia and systemic TNF and IL-1u03b2 expression. This study has a number of limitations.
- future: More studies are required to determine the translational potential of targeting JAM-A.
SUMMARY
Sepsis is a life-threatening organ dysfunction caused . . .
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