Jund is required for proliferation of prostate cancer cells and plays a role in transforming growth factor-β (tgf-β)-induced inhibition of cell proliferation*

HIGHLIGHTS

• who: Ana Cecilia Millena from the Ana Cecilia Millena, BaoHan TVo1, and Shafiq A. Khan, From the Center for Cancer Research and Therapeutic Development, Clark Atlanta University, Atlanta, Georgia , TGF-␤ inhibits proliferation of prostate epithelial cells. However, prostate cancer cells in advanced stages become resistant to inhibitory effects of TGF-␤. The intracellular signaling mechanisms involved in differential effects of TGF-␤ during different stages are largely unknown. Using cell line models, we have shown that TGF-␤ inhibits proliferation in normal (RWPE-1) and prostate cancer (DU145) cells but does not have any effect on proliferation of prostate cancer . . .
  

   

  

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