HIGHLIGHTS
- who: Haocheng Zhou from the Xiangya Hospital South University, Changsha , Hunan Province, China have published the article: Ketamine reduces aversion in rodent pain models by suppressing hyperactivity of the anterior cingulate cortex, in the Journal: NATURE COMMUNICATIONS NATURE COMMUNICATIONS
- how: To verify that inhibition of ACC hyperactivity is a mechanism for the enduring anti-aversive effect of ketamine in the chronic pain state the authors used optogenetics and in_vivo pharmacology to alter the activity levels of excitatory pyramidal neurons in the ACC of CFA-treated rats. CPA experiments were conducted in a two-chamber device826 . . .
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