HIGHLIGHTS
- who: Protein Degradation Drug Discovery and collaborators from the University, Hefei, China have published the research: Key Considerations in Targeted Protein Degradation Drug Discovery and Development, in the Journal: (JOURNAL)
- how: The molecules were tested in the HEK293 T_cell line transduced with FLAG-tagged FKBP12 either with or without C-terminal NLS (nuclear localization sequence) KKKRKV.
SUMMARY
E3 ligases beyond VHL and CRBN for targeted protein degradation, for example, tissue-specific or diseasespecific E3 ligases would considerably expand the application of targeted protein degradation for therapeutic purposes (Kannt and Đikić 2021 . . .
If you want to have access to all the content you need to log in!
Thanks :)
If you don't have an account, you can create one here.