Key modulators of the stress granule response tia1, tdp-43, and g3bp1 are altered by polyglutamine-expanded atxn7

HIGHLIGHTS

• who: Frida Niss from the Department of Biochemistry and Biophysics, Stockholm University, Stockholm, Sweden have published the Article: Key Modulators of the Stress Granule Response TIA1, TDP-43, and G3BP1 Are Altered by Polyglutamine-Expanded ATXN7, in the Journal: (JOURNAL)
• what: The authors show that two SG-related proteins TDP-43 and TIA1 are sequestered into the aggregates formed by polyQ-expanded ATXN7 in SCA7 cells.
• how: For this the authors used a CellProfiler pipeline to assay variance determining the texture of the signal. In light of the effect ATXN7Q65 induction had on . . .
  

   

  

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