Kinetic and thermodynamic analysis defines roles for two metal ions in dna polymerase specificity and catalysis

HIGHLIGHTS

• who: Shanzhong Gong from the Shanzhong Gong1, Serdal Kirmizialtin2, Adrienne Chang2, Joshua EMayfield1, Yan Jessie Zhang1, and Kenneth A. Johnson1, * From the Department of Molecular Biosciences, The University of Texas at Austin, Austin, Texas, USA have published the Article: Kinetic and thermodynamic analysis defines roles for two metal ions in DNA polymerase specificity and catalysis, in the Journal: (JOURNAL) of October/19,/2020
• what: The authors show that Mg.dNTP binding induces an enzyme conformational change at a rate that is independent of free Mg2+ concentration. Global fitting of the two experiments at each Mg2 . . .
  

   

  

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