HIGHLIGHTS
- who: Dae-yeol Ye from the (UNIVERSITY) have published the paper: Kinetic compartmentalization by unnatural reaction for itaconate production, in the Journal: (JOURNAL) of 29/08/2022
SUMMARY
Aspergillus terreus, a native itaconate producer, facilitates spatial compartmentalization of cis-aconitate by pumping out mitochondrial cis-aconitate into the cytosol by exchanging cytosolic oxaloacetate via an antiporter, MttA (Supplementary Nature Communications | 13:5353 Citrate Citrate PrpD* cis- Aconitate cisAconitate AcnB Cad Cad Isocitrate Isocitrate TCA cycle AcnB* Itaconate TCA cycle Itaconate to secure cis-aconitate, resulting in increased itaconate production. H444 functions as a . . .
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