HIGHLIGHTS
- who: January et al. from the BioInnovation Institute (BII), Denmark University of Massachusetts Lowell have published the research: Knocking out central metabolism genes to identify new targets and alternating substrates to improve lipid synthesis in, in the Journal: (JOURNAL)
- how: The result showed that NADPH sources for lipogenesis include the OxPP pathway POM cycle and a trans-mitochondrial isocitrate-u03b1-oxoglutarate NADPH shuttle in Y. lipolytica.
SUMMARY
Systematic gene knockout studies may offer the authors novel insights on cell metabolism and physiology. Specifically, the lipid accumulation mechanism at the molecular or . . .
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