HIGHLIGHTS
- who: Kuen Kuen Lam and collaborators from the Second Military Medical University, China have published the Article: KRAS-specific antibody binds to KRAS protein inside colorectal adenocarcinoma cells and inhibits its localization to the plasma membrane, in the Journal: (JOURNAL)
- what: The authors propose a mode of action of anti-KRAS antibody in inhibition of KRAS signaling and inner plasma_membrane localization .
- how: The authors developed a transient ex vivo culture from CRC patients` tumor and matched mucosa tissues as a model to test for anti-KRAS antibody internalization.
SUMMARY
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