Kynurenic acid protects against ischemia/reperfusion injury by modulating apoptosis in cardiomyocytes

HIGHLIGHTS

• What: The authors aimed to further investigate the potential molecular and cellular mechanisms contributing to the cardiocytoprotective effect of KYNA. As apoptotic cell death plays a fundamental role in I/R-induced cardiac tissue damage, Apoptosis 29:1483-1498 here the authors aimed to analyze if KYNA administration counteracts the I/R-triggered proapoptotic signaling. Next the authors focused on further examination of possible underlying antiapoptotic mechanisms in the SI/R setting. Based on these results the authors propose that the modulation of caspase activation is involved in the KYNA-associated cytoprotection against SI/R. This modulatory . . .
  

   

  

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