Kynurenine 3-monooxygenase interacts with huntingtin at the outer mitochondrial membrane

HIGHLIGHTS

• who: Aisha M. Swaih et al. from the Department of Genetics and Genome Biology, University of Leicester, Leicester , RH, UK have published the research: Kynurenine 3-Monooxygenase Interacts with Huntingtin at the Outer Mitochondrial Membrane, in the Journal: Biomedicines 2022, 10, x FOR PEER REVIEW of 29/08/2022
• what: This study shows that KMO and HTT can physically interact at the outer mitochondrial membrane, and that this interaction is disrupted by polyQ expansion, which reduces the pool of soluble HTT available at the mitochondria.
• how: For HTT the authors used previously validated . . .
  

   

  

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