Kynurenines increase MRS metabolites in basal ganglia and decrease resting-state connectivity in frontostriatal reward circuitry in depression

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• who: Xiangchuan Chen from the laboratory animals, blocking KP activation through inhibition of IDO or inhibiting the transport of KYN into the brain using leucine or blocking of NMDA receptors with ketamine can reverse inflammation-induced depressive-like behavior [20, , ]Nevertheless, no study has examined the associations of plasma and CSF KP metabolites with MRS and rsfMRI measures (Glu, myoinositol, ReHo, and connectivity). We, therefore, examined the impact of plasma and CSF KP on brain chemistry and the function of basal ganglia using MRS and rsfMRI. We hypothesized that increased plasma or CSF KP measures would be . . .
  

   

  

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