L-tyrosine-bound thih structure reveals c-c bond break differences within radical sam aromatic amino acid lyases

HIGHLIGHTS

• who: Patricia Amara from the CEA have published the Article: L-tyrosine-bound ThiH structure reveals C-C bond break differences within radical SAM aromatic amino acid lyases, in the Journal: NATURE COMMUNICATIONS NATURE COMMUNICATIONS
• what: The authors report the crystal_structure of ThiH from Thermosinus carboxydivorans (Tc) in complex with its L-tyrosine substrate. By combining X-ray crystallography and computational chemistry, the authors provide a rarely achieved mechanistic insight into the hydrogen-atom abstraction step catalyzed by radical SAM enzymes and underscore how subtle changes at the active_site afford both substrate selectivity and chemical . . .
  

   

  

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