Lack of a protective effect of the tmem106b “protective snp” in the grn knockout mouse model for frontotemporal lobar degeneration

HIGHLIGHTS

  • who: Anne-Sophie Cabron from the Institute of Biochemistry, Christian-Albrechts-University Kiel, Olshausenstr40, Kiel, Germany have published the research work: Lack of a protective effect of the Tmem106b u201cprotective SNPu201d in the Grn knockout mouse model for frontotemporal lobar degeneration, in the Journal: (JOURNAL)
  • what: The authors aimed to investigate the relevance and function of the T186S variant in_vivo in a Tmem106b knockin mouse that harbors the serine in amino_acid position 186 instead of the threonine in wildtype mice.
  • how: The authors analyzed the effect of this variant on pathology by crossing . . .

     

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