Lactate transporter monocarboxylate transporter 4 induces bone pain in head and neck squamous cell carcinoma

HIGHLIGHTS

  • who: Kazuaki Hasegawa and colleagues from the Departments of Oral and Maxillofacial Surgery Okayama University Graduate School of Medicine have published the research work: Lactate Transporter Monocarboxylate Transporter 4 Induces Bone Pain in Head and Neck Squamous Cell Carcinoma, in the Journal: (JOURNAL)
  • what: The experiments demonstrated that the inhibition of 4 (MCT4) by short hairpin (shRNA) transduction suppressed the HNSCC-BP the level in bone marrow and the pERK1/2 expression in DRG. The authors evaluated whether the expression of another (ASIC3) in sensory neurons . The authors propose that the low pH of HNSCC . . .

     

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