HIGHLIGHTS
- who: Tanay Thakar from the (UNIVERSITY) have published the research work: Lagging strand gap suppression connects BRCA-mediated fork protection to nucleosome assembly through PCNA-dependent CAF-1 recycling, in the Journal: (JOURNAL) of 15/02/2022
- what: The authors report that lagging_strand ssDNA gaps interfere with the ASF1-CAF-1 nucleosome assembly pathway, and drive fork degradation in BRCA-deficient cells. The authors show that CAF-1 function at replication forks is lost in BRCA-deficient cells, due to defects in its recycling during replication stress. The authors show that ASF1A inactivation is epistatic . . .
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