Lamin a/c augments th1 differentiation and response against vaccinia virus and leishmania major

HIGHLIGHTS

• who: Raquel Toribio-Fernández from the (UNIVERSITY) have published the research: Lamin A/C augments Th1 differentiation and response against vaccinia virus and Leishmania major, in the Journal: (JOURNAL)
• what: The authors demonstrate that the absence of in naive T-cell reduces differentiation without affecting differentiation in vitro and in vivo. The authors show that lamin A/C expression augments CD4+ T-cell Th1 differentiation in response to pathogen infection by regulating T-bet transcription factor expression and IFNγ production. The authors have identified the nuclear envelope protein lamin A/C as a crucial . . .
  

   

  

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