Lamins and nesprin-1 mediate inside-out mechanical coupling in muscle cell precursors through fhod1

HIGHLIGHTS

• who: Christine Schwartz from the Paris, France Univ. Grenoble Alpes, LIPHY, Grenoble, France. CNRS, LIPHY, Grenoble, France. Street Biomedical Research Centre, Institute of Child Health, University College London, Guilford Street, London have published the paper: Lamins and nesprin-1 mediate inside-out mechanical coupling in muscle cell precursors through FHOD1, in the Journal: Scientific Reports Scientific Reports of 27/03/2017
• what: The authors show that pathogenic mutations in LMNA or SYNE-1 responsible for severe muscle dystrophies reduced the ability of human muscle cell precursors to adapt to substrates of different stiffness.
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