Large meta-analysis of genome-wide association studies identifies five loci for lean body mass

HIGHLIGHTS

• who: M. Carola Zillikens from the (UNIVERSITY) have published the article: Large meta-analysis of genome-wide association studies identifies five loci for lean body mass, in the Journal: NATURE COMMUNICATIONS NATURE COMMUNICATIONS
• what: The authors focused on two phenotypes: whole body lean mass; appendicular lean mass.
• how: To estimate the proportion of variance for lean mass explained by all genotyped SNPs across the genome in Framingham Study participants the authors applied a GREML model implemented in the GCTA package49 with the assumption that all 550K genotyped SNPs captured ≥80% of the common . . .
  

   

  

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