Large-scale conformational changes of fhac provide insights into the two-partner secretion mechanism

HIGHLIGHTS

  • who: James A. Garnett and colleagues from the United Kingdom University of Connecticut have published the Article: Large-Scale Conformational Changes of FhaC Provide Insights Into the Two-Partner Secretion Mechanism, in the Journal: (JOURNAL)
  • what: The authors have explored such FhaC conformers using biophysical techniques suitable to detect minor states in heterogeneous populations. The authors propose that this peptide binds to the B1 strand of the partially unzipped barrel seam based on the following reasoning. Although the next secretion steps are speculative, the authors propose the following model based on earlier work.
 

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