Large-scale functional genomics screen to identify modulators of human -cell insulin secretion

HIGHLIGHTS

• who: Iwona Szczerbinska and collaborators from the Department of Discovery Biology and Pharmacology, Novo Nordisk Research Centre Oxford, Department of Health Technology, Technical University of Denmark, Copenhagen, Denmark have published the paper: Large-Scale Functional Genomics Screen to Identify Modulators of Human -Cell Insulin Secretion, in the Journal: Biomedicines 2022, 10, 103. of 29/Nov/2021
• what: The authors note that the approach has several limitations.
• how: For independent validation of the hits from the large-scale screen the authors selected activating transcription factor 4 (ATF4) and heat-shock protein family A (Hsp70 . . .
  

   

  

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