Lasmiditan ameliorates serotonergic itch in mice: possible involvement of 5-ht1f receptors

HIGHLIGHTS

• What: The authors aimed to investigate the efficacy of lasmiditan a highly selective agonist of the 5-Hydroxytriptamin 1F receptor (5-HT1FR) and a recently approved medication for the treatment of migraine headaches in ameliorating serotonergic itching. The authors aimed to investigate whether lasmiditan could ameliorate serotonergic itch and if so, whether it exerts its antipruritic activity by interacting with peripheral 5-HT1F receptors and modulating peripheral CGRP levels. In this study, male Naval Medical Research Institute (NMRI) mice from Tehran University of Medical Sciences were investigated, aged 5-6 weeks (outbred, mean age=5.2), and . . .
  

   

  

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