HIGHLIGHTS
- who: Wenhua Cai from the Capital Medical University, China have published the Article: LDC7559 inhibits microglial activation and GSDMD-dependent pyroptosis after subarachnoid hemorrhage, in the Journal: (JOURNAL)
- how: The immunofluorescence staining results showed that microglial activation was significantly induced after SAH which could be dose-dependently suppressed by LDC7559 . Yuan et_al indicated that inhibition of absent in melanoma 2 (AIM2) inflammasome previous reports the data indicated that LDC7559 dramatically inhibited microglial activation and the pro-inflammatory cytokines release after SAH. The data showed that LDC7559 did not affect caspase-1 expression.
SUMMARY . . .
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