HIGHLIGHTS
- who: QCA and colleagues from the Wuyi University, China have published the paper: Lethal activity of BRD4 PROTAC degrader QCA570 against bladder cancer cells, in the Journal: (JOURNAL)
- what: The authors evaluated the activity of QCA570 on BC cell lines. The authors observed after analyzing data from TGCA and GEO, that BRD4 was upregulated in BC tissues as compared to the corresponding normal bladder tissues.
- how: The results were analyzed using GraphPad software. The Western blotting (WB) result showed that BRD4 degradation was almost completely abolished by pre-treatment with the proteasome inhibitor . . .
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