Leucine-973 is crucial residue differentiating insulin section of integrative physiology and metabolism joslin diabetes center harvard medical

HIGHLIGHTS

• who: Hirofumi Nagao and colleagues from the Department University of USA have published the article: Leucine-973 is crucial residue differentiating insulin Section of Integrative Physiology and Metabolism Joslin Diabetes Center Harvard Medical, in the Journal: (JOURNAL)
• what: The authors show that replacement of a single amino acid at position 973 just distal to the NPEY motif in the intracellular juxtamembrane region from leucine which is highly conserved in IRs to phenylalanine the highly conserved homologous residue in IGF1Rs resulted in decreased IRS-1/PI3K/Akt/mTORC1 signaling and increased Shc/Gab1/MAPK cell cycle . . .
  

   

  

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