Leukocyte nuclear morphology alterations in dilated cardiomyopathy caused by a lamin ac truncating mutation (lmna/ser431*) are modified by the presence of a lap2 missense polymorphism (tmpo/arg690cys)

HIGHLIGHTS

• who: Antonia Gonzu00e1lez-Garrido and colleagues from the Laboratorio Enfermedades Mendelianas, Instituto Medicina Genu00f3mica, Mexico City, Mexico Departamento Ciencias Naturales, Universidad Autu00f3noma Metropolitana, Unidad Cuajimalpa have published the paper: Leukocyte Nuclear Morphology Alterations in Dilated Cardiomyopathy Caused by a Lamin AC Truncating Mutation (LMNA/Ser431*) Are Modified by the Presence of a LAP2 Missense Polymorphism (TMPO/Arg690Cys), in the Journal: (JOURNAL) of 26/Oct/2022
• future: Studies are required to assess the possible clinical translation of these findings.

SUMMARY

DCMassociated LMNA mutations have been found to alter the nuclear lamin structure . . .

 



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