Leveraging pleiotropy for joint analysis of genome-wide association studies with per trait interpretations

HIGHLIGHTS

  • who: Kodi Taraszka and colleagues from the Department of Computer Science, University of California, Los Angeles, California, United States of have published the Article: Leveraging pleiotropy for joint analysis of genome-wide association studies with per trait interpretations, in the Journal: (JOURNAL) of February/28,/2022
  • what: In simulations the authors show PAT controls the false positive rate increases statistical power and is robust to model misspecifications of genetic effect. The authors propose a method that leverages this genetic architecture and uses summary statistics to perform an omnibus association test between one genetic variant and . . .

     

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