HIGHLIGHTS
- who: Zijian Fang and colleagues from the University of Cambridge, Cambridge , AW, UK have published the Article: Ligand-Specific Factors Influencing GLP-1 Receptor Post-Endocytic Trafficking and Degradation in Pancreatic Beta Cells, in the Journal: (JOURNAL)
- what: The authors have explored the post-endocytic sorting of GLP-1R after treatment with GLP-1 or exendin-4. The authors focus in particular on ligand-specific differences in receptor degradation, which may in turn contribute to receptor availability and insulin secretory responses during prolonged pharmacological stimulation. The authors investigate the importance of intra-endosomal ligand proteolysis . . .
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