HIGHLIGHTS
SUMMARY
The phenomenon of consanguinity, in which unions occur between closely related individuals, is a form of population structure that can dramatically affect properties of genetic variation (Crow and Kimura, 1970; Jacquard, 1974). By increasing the probability that deleterious recessive variants appear in homozygous form, it contributes to the incidence of recessive disease (Bittles, 2001; Woods et_al, 2006); recent studies suggest that it contributes to incidence of complex disease as well (Bittles and Black, 2010; Yengo et_al, 2017; Ceballos et_al, 2018; Johnson et_al, 2018; Clark et_al, 2019). Consanguinity is common in human populations, with some . . .
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