Linagliptin in combination with metformin ameliorates diabetic osteoporosis through modulating bmp-2 and sclerostin in the high-fat diet fed c57bl/6 mice

HIGHLIGHTS

• who: Nikita Nirwan from the Neurobehavioral Pharmacology Laboratory, Department of Pharmacology, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi, India Emory University, United States have published the paper: Linagliptin in Combination With Metformin Ameliorates Diabetic Osteoporosis Through Modulatingu00a0BMP-2 and Sclerostin in the High-Fat Diet Fed C57BL/6 Mice, in the Journal: (JOURNAL)
• what: We conclude that improvement in bone architecture, BMD, bone turnover biomarkers, and bone histopathology by the combination of linagliptin and metformin shows its bone protective potential in reversing HFD-induced diabetic osteoporosis which is possibly mediated through modulation . . .
  

   

  

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