HIGHLIGHTS
- who: Mariateresa Casarotto from the Oncologico di Aviano (CRO), IRCCS, Aviano, Italy have published the paper: LINE-1 hypomethylation is associated with poor outcomes in locoregionally advanced oropharyngeal cancer, in the Journal: (JOURNAL)
- what: To identify DNA methylation alterations within the promoter regions, the authors focused on CpG sites located within the TSS1500, TSS200, 5` UTR, and first exon. The authors focused in particular on hypomethylated and up-regulated genes, thereby identifying 20 genes (Fig 5a, Additional file 4: Table S4), most of which (16/20) overlapped with LINE-1 elements (Additional file 6: Figure . . .
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