Lipid environment determines the drug-stimulated atpase activity of p-glycoprotein

HIGHLIGHTS

  • who: P-glycoprotein and collaborators from the University of Texas Health Science Center at Houston, United States have published the research: Lipid environment determines the drug-stimulated ATPase activity of P-glycoprotein, in the Journal: (JOURNAL)

SUMMARY

    Lipids (e_g, tissue extracts from E. coli, sheep or bovine brain, bovine liver, for available lipid composition see Table 1). The basal activity (in the absence of added drug) and the drug-stimulated activities varied considerably depending on the detergent used for solubilization and the lipid source (Ambudkar et_al, 1992; Sharom et_al, 1993; Urbatsch and Senior . . .

     

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