Lipid-induced epigenomic changes in human macrophages identify a coronary artery disease-associated variant that regulates ppap2b expression through altered c/ebp-beta binding

HIGHLIGHTS

• who: Michael E. Reschen and collaborators from the Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom, Nuffield have published the article: Lipid-Induced Epigenomic Changes in Human Macrophages Identify a Coronary Artery Disease-Associated Variant that Regulates PPAP2B Expression through Altered C/EBP-Beta Binding, in the Journal: (JOURNAL)
• what: The study demonstrates hitherto unknown genetic mechanism underlying atherosclerotic heart disease and demonstrates the value of studying changes in transcriptional regulation in key disease processes involving environmental influences. The authors employ FAIRE-seq and ChIP-seq assays to, first, show that . . .
  

   

  

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