HIGHLIGHTS
- who: You Zhou from the United States Australian National University, Australia have published the research: Lipoxin A4 attenuates MSU-crystal-induced NLRP3 inflammasome activation through suppressing Nrf2 thereby increasing TXNRD2, in the Journal: (JOURNAL)
- what: The authors propose that LXA4 blunts MSU-crystal-induced ROS generation due to the suppression of NADPH oxidase activation and improvement of mitochondrial dysfunction. This study demonstrated that LXA4 is a reliable inhibitor for the NLRP3 inflammasome stimulated by MSU crystals. The authors demonstrated that LXA4 did not suppress the expression of NLRP3, ASC, pro-IL-1b, and pro-caspase . . .
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