HIGHLIGHTS
SUMMARY
Circulating extracellular nucleic_acids (cell-free DNA; cfDNA) and circulating tumor DNA (ctDNA) can be isolated from the blood. cfDNA is DNA freely circulating in the blood, which may or may not be of tumor origin, whereas ctDNA is of tumor origin. CAPP-Seq identifies alterations in ctDNA/cfDNA using large genomic libraries and individual patient sample sequence signatures. The following will be discussed in this section: differentiating unique immune checkpoint blockade response patterns, predicting immune checkpoint blockade response, assessing shed DNA from multiple metastatic sites/tumor heterogeneity, assessing potentially actionable alterations, serial sampling for . . .
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