HIGHLIGHTS
- who: Christopher A. Koczor and colleagues from the Department of Pharmacology, College of Medicine, University of South Alabama, Mobile, AL, USA have published the research work: Live Cell Detection of Poly(ADP-Ribose) for Use in Genetic and Genotoxic Compound Screens, in the Journal: Cancers 2022, 3676 of /2022/
- what: The authors show that both approaches can identify genetic modifications that alter PARylation levels such as hyper-PARylation in BRCA2-deficient cancer cells. The authors demonstrate the utility of the split luciferase assay to characterize the cellular response of genotoxins PARP inhibitors and PARG inhibitors . . .
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