Liver receptor homolog 1 transcriptionally regulates human bile salt export pump expression*

HIGHLIGHTS

• who: Xiulong Song from the DepartmentUniversity of have published the paper: Liver receptor homolog 1 transcriptionally regulates human bile salt export pump expression*, in the Journal: (JOURNAL) of 17/09/2007
• what: The authors demonstrate that LRH-1 transcriptionally regulates BSEP expression through a functional liver receptor homolog 1-responsive element (LRHRE) in the BSEP promoter and functions as a modulator in bile acid/ FXR-mediated BSEP regulation. The authors explored the potential regulatory role of SHP in BSEP expression and found that SHP dose- dependently repressed LRH-1-mediated transactivation of BSEP promoter, consistent . . .
  

   

  

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